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Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements

4 Apr 2025

Abstract excerpt

Telomeres, the DNA-protein complex located at the ends of linear eukaryotic chromosomes, not only safeguard genetic information from DNA erosion and aberrant activation of the DNA damage response pathways but also play a pivotal role in sexual reproduction. During meiotic prophase I, telomeres attach to the nuclear envelope and migrate along its surface, facilitating two-dimensional DNA homology searches that...

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PMID: 40261310
DOI: 10.1083/jcb.202412135

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