F‐box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β‐catenin function

Abstract excerpt

Abstract Aberrant activation of β‐catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β‐catenin‐signaling pathways is still poorly understood. In this study, we show that F‐box protein 16 (FBXO16) is a putative tumor suppressor. It is a component of the SCF (SKP1‐Cullin1‐F‐box protein) complex, which targets the nuclear...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Ubiquitin and proteasome pathways
• Share to Wnt/β-catenin signaling in development and cancer