Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Abstract excerpt

Abstract The derivation of kidney tissues from human pluripotent stem cells (hPSCs) and its application for replacement therapy in end-stage renal disease have been widely discussed. Here we report that consecutive transfections of two sets of synthetic mRNAs encoding transcription factors can induce rapid and efficient differentiation of hPSCs into kidney tissues, termed induced nephron-like organoids...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pluripotent Stem Cells Research
• Share to Renal and related cancers
• Share to Renal cell carcinoma treatment