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Article

Uterine adenosarcomas are mesenchymal neoplasms.

The Journal of pathology - 1 Feb 2016

Piscuoglio Salvatore, Burke Kathleen A, Ng Charlotte K Y, Papanastasiou Anastasios D, Geyer Felipe C, Macedo Gabriel S, Martelotto Luciano G, de Bruijn Ino, De Filippo Maria R, Schultheis Anne M, Ioris Rafael A, Levine Douglas A, Soslow Robert A, Rubin Brian P, Reis-Filho Jorge S, Weigelt Britta

Abstract excerpt

Uterine adenosarcomas (UAs) are biphasic lesions composed of a malignant mesenchymal (ie stromal) component and an epithelial component. UAs are generally low-grade and have a favourable prognosis, but may display sarcomatous overgrowth (SO), which is associated with a worse outcome. We hypothesized that, akin to breast fibroepithelial lesions, UAs are mesenchymal neoplasms in which clonal somatic genetic...

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Source

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Identifiers

PMID: 26592504
DOI: 10.1002/path.4675
PMCID: PMC4986517

Genes

CDK4
DICER1
FGFR2
HMGA2
MDM2
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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