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Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation

20 Jan 2019

Abstract excerpt

BACKGROUND: Ubiquinol-cytochrome C reductase core protein II (QCR2) is essential for mitochondrial functions, yet, its role in cancer development has remained elusive. METHODS: The expression of QCR2 in cancer patients was assessed by immunohistochemistry. The proliferation of cancer cells was assessed by CCK-8 assay, EdU staining and Flow cytometry analysis. The biological function of QCR2 and PHB were...

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PMID: 30674441
DOI: 10.1016/j.ebiom.2019.01.002

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