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MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer

12 Oct 2023

Abstract excerpt

BACKGROUND: The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of leucine and isovaleric acid. The molecular mechanisms and prognostic value still need to be explored in the context of specific cancers, including colorectal cancer (CRC). METHODS: In vitro and in vivo cell-based assays were performed to explore the role of MCCC2 in CRC...

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PMID: 37828426
DOI: 10.1186/s11658-023-00487-0

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