Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.

doi:10.1038/mt.2014.219

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Article

Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2015

Schönfeld Kurt, Sahm Christiane, Zhang Congcong, Naundorf Sonja, Brendel Christian, Odendahl Marcus, Nowakowska Paulina, Bönig Halvard, Köhl Ulrike, Kloess Stephan, Köhler Sylvia, Holtgreve-Grez Heidi, Jauch Anna, Schmidt Manfred, Schubert Ralf, Kühlcke Klaus, Seifried Erhard, Klingemann Hans G, Rieger Michael A, Tonn Torsten, Grez Manuel, Wels Winfried S

Abstract excerpt

Natural killer (NK) cells are an important effector cell type for adoptive cancer immunotherapy. Similar to T cells, NK cells can be modified to express chimeric antigen receptors (CARs) to enhance antitumor activity, but experience with CAR-engineered NK cells and their clinical development is still limited. Here, we redirected continuously expanding and clinically usable established human NK-92 cells to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25373520
DOI: 10.1038/mt.2014.219
PMCID: PMC4445620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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