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Article

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

Blackmore Murray G, Wang Zimei, Lerch Jessica K, Motti Dario, Zhang Yi Ping, Shields Christopher B, Lee Jae K, Goldberg Jeffrey L, Lemmon Vance P, Bixby John L

Abstract excerpt

Axon regeneration in the central nervous system normally fails, in part because of a developmental decline in the intrinsic ability of CNS projection neurons to extend axons. Members of the KLF family of transcription factors regulate regenerative potential in developing CNS neurons. Expression of one family member, KLF7, is down-regulated developmentally, and overexpression of KLF7 in cortical neurons in vitro...

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Identifiers

PMID: 22529377
DOI: 10.1073/pnas.1120684109
PMCID: PMC3358880

Genes

KLF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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