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CA 10 and CA 11 negatively regulate neuronal activity‐dependent growth of gliomas

12 Jan 2019

Abstract excerpt

Recent studies have revealed that neurons can promote glioma growth through activity-dependent secretion of neurotrophins, especially neuroligin-3. It has therefore been suggested that blocking neuron-derived neurotrophins may serve as a therapeutic intervention for gliomas. Carbonic anhydrase-related proteins 11 and 10 (CA11 and CA10) are secreted synaptic proteins which function as neurexin ligands, and the...

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PMID: 30636076
DOI: 10.1002/1878-0261.12445

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