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Article

Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation

26 Dec 2018

Abstract excerpt

Bone-resorbing osteoclasts (OCs) are derived from myeloid precursors (MPs). Several transcription factors are implicated in OC differentiation and function; however, their hierarchical architecture and interplay are not well known. Analysis for enriched motifs in PU.1 and MITF chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) data from differentiating OCs identified eomesodermin...

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PMID: 30634169
DOI: 10.1016/j.isci.2018.12.018

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