Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk

Abstract excerpt

Background Several studies have shown effects of current and maternal smoking during pregnancy on DNA-methylation of CpG sites in newborns and later in life. Here we hypothesized that there are long-term and persistent epigenetic effects following maternal smoking during pregnancy on adolescent offspring DNA methylation, independent of paternal and postnatal smoke exposure. Further, we explored the association...

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