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Article

Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer

11 Jul 2016

Abstract excerpt

The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation of co-inhibitory B7 molecules is associated with reduced antitumor immunity and cancer immune evasion. FDA approval of cancer immunotherapy antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1)-both ligands of the B7 family-demonstrate the impact of...

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PMID: 27622076
DOI: 10.1080/2162402x.2016.1207841

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