Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

1 Dec 2018

Abstract excerpt

BACKGROUND: TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, can selectively kill cancer cells with little or no cytotoxicity toward normal human cells and is regarded as a potential relatively safe antitumor drug. However, some cancer cells are resistant to TRAIL-induced apoptosis. Thus, reagents that potentiate TRAIL-induced cytotoxicity are needed. Herein, we investigated whether shikonin, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cell death mechanisms and regulation
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30594131
DOI: 10.1186/s12860-018-0179-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathwaysPMID 30594131Read ↗

Shikonin, an Ingredient of Lithospermum erythrorhizon Induced Apoptosis in HL60 Human Premyelocytic Leukemia Cell LineSemantic proximity Read ↗

Shikonin Ameliorates Rotenone-Induced Neurotoxicity Through Inhibition of Apoptosis via IGF-1R/PI3K/AKT Pathway in a Parkinson’s Disease-Associated SH-SY5Y Cell ModelSemantic proximity Read ↗

Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis InductionSemantic proximity Read ↗

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.Semantic proximity Read ↗

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2.Semantic proximity Read ↗

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.Semantic proximity Read ↗

TRAIL Promotes Epithelial-to-mesenchymal Transition by Inducing PD-L1 Expression in Esophageal Squamous Cell CarcinomasSemantic proximity Read ↗

Shikonin causes apoptosis by up-regulating p73 and down-regulating ICBP90 in human cancer cellsSemantic proximity Read ↗

Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca‐8113 cell lines by shikonin was partly through the inactivation of NF‐<i>κ</i>B pathwaySemantic proximity Read ↗

SL4, a chalcone‐based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathwaySemantic proximity Read ↗

Involvement of DR4/JNK pathway-mediated autophagy in acquired TRAIL resistance in HepG2 cellsSemantic proximity Read ↗

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.