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Article

SL4, a chalcone‐based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway

26 Oct 2015

Abstract excerpt

OBJECTIVES: SL4, a chalcone-based compound, exhibits clearly inhibitory effects on HIF-1 and has been shown to effectively suppress tumour invasion and angiogenesis in vitro and in vivo. Here, studies were conducted to determine SL4's anti-apoptotic effects and its underlying mechanisms, in human cancer cells. MATERIALS AND METHODS: Cytotoxicity, apoptotic induction and its involved mechanisms of SL4 were...

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PMID: 26500049
DOI: 10.1111/cpr.12226

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