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Shikonin, an Ingredient of Lithospermum erythrorhizon Induced Apoptosis in HL60 Human Premyelocytic Leukemia Cell Line

1 Aug 1999

Abstract excerpt

Apoptosis is a new therapeutic target of cancer research. Shikonin isolated from Lithospermum erythrorhizon, a traditional oriental medicinal herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Shikonin induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide staining. The increase of...

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PMID: 10483373
DOI: 10.1055/s-1999-14010

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Shikonin, an Ingredient of Lithospermum erythrorhizon Induced Apoptosis in HL60 Human Premyelocytic Leukemia Cell LinePMID 10483373Read ↗

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