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Article

Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish

26 Dec 2018

Abstract excerpt

Abstract Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9. sox3 knockout led to follicle development retardation and a reduced fecundity in females. Comparative analysis of transcriptome...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30588557
DOI: 10.1007/s13238-018-0603-y

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