Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway

18 Dec 2018

Abstract excerpt

Mounting evidence has demonstrated that angiogenesis plays an important role in tumour progression. However, the key regulators in tumour angiogenesis remain unclear. Recently, emerging reports have indicated that SIRT2 plays critical roles in proliferation, metastasis and tumourigenesis in diverse tumours. However, the function of SIRT2 in tumour angiogenesis and the mechanism underlying the regulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30584257
DOI: 10.1038/s41419-018-1260-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathwayPMID 30584257Read ↗

Role of Sirtuins in Tumor AngiogenesisSemantic proximity Read ↗

SIRT2, a direct target of miR‐212‐5p, suppresses the proliferation and metastasis of colorectal cancer cellsSemantic proximity Read ↗

Discovery of a novel small-molecule activator of SIRT3 that inhibits cell proliferation and migration by apoptosis and autophagy-dependent cell death pathways in colorectal cancerSemantic proximity Read ↗

SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor DasatinibSemantic proximity Read ↗

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathwaySemantic proximity Read ↗

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signaling pathwaySemantic proximity Read ↗

SIRT1 downregulated FGB expression to inhibit RCC tumorigenesis by destabilizing STAT3Semantic proximity Read ↗

SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of SnailSemantic proximity Read ↗

miR-622 inhibits angiogenesis by suppressing the CXCR4–VEGFA axis in colorectal cancerSemantic proximity Read ↗

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent mannerSemantic proximity Read ↗

MicroRNA-340 inhibits the growth and invasion of angiosarcoma cells by targeting SIRT7Semantic proximity Read ↗

SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.