Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signaling pathway

Abstract excerpt

<title>Abstract</title> <p>Background Anti-angiogenesis therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that tumor microenvironment (TME) promotes tumour angiogenesis. Bufalin is an active compound whose anti-tumor efficacy has been proven by previous studies. However, there are very few studies on the anti-angiogenic effects of bufalin. Met...

Topics

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• Angiogenesis Inhibitors
• Biomarkers, Tumor
• Drug Resistance, Neoplasm
• Neoplasm Metastasis
• Neoplasms
• Polymorphism, Single Nucleotide
• Stromal Cells
• Vascular Endothelial Growth Factor A

Identifiers and source

Literature Corpus work

a1b28ff1-1ac0-58f1-9f62-0ade16079dd4

DOI

10.21203/rs.3.rs-222601/v1