Article
Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes.
Reviews of infectious diseases - 1 Jan 2000
Sougakoff W, Goussard S, Gerbaud G, Courvalin P
Abstract excerpt
Infections due to strains of Klebsiella pneumoniae, Escherichia coli, and Citrobacter freundii resistant to third-generation cephalosporins have been observed recently in France and the Federal Republic of Germany. This resistance phenotype is due to the production of new plasmid-mediated, broad-substrate-range beta-lactamases designated TEM-3 to TEM-7. DNA-DNA hybridization analysis with a probe specific for...
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