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Article

Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes.

Reviews of infectious diseases - 1 Jan 2000

Sougakoff W, Goussard S, Gerbaud G, Courvalin P

Abstract excerpt

Infections due to strains of Klebsiella pneumoniae, Escherichia coli, and Citrobacter freundii resistant to third-generation cephalosporins have been observed recently in France and the Federal Republic of Germany. This resistance phenotype is due to the production of new plasmid-mediated, broad-substrate-range beta-lactamases designated TEM-3 to TEM-7. DNA-DNA hybridization analysis with a probe specific for...

Topics

Amino Acid Sequence
Base Sequence
Cephalosporins
Citrobacter
Cloning, Molecular
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Humans
Klebsiella pneumoniae
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Hybridization

Penicillinase

R Factors

Sequence Homology, Nucleic Acid

Transformation, Bacterial

Source

Identifiers

PMID: 3055179
DOI: 10.1093/clinids/10.4.879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3055179-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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