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Article

A new example of physical linkage between Tn1 and Tn21: the antibiotic multiple-resistance region of plasmid pCFF04 encoding extended-spectrum beta-lactamase TEM-3.

Molecular & general genetics : MGG - 1 Oct 1992

Mabilat C, Lourençao-Vital J, Goussard S, Courvalin P

Abstract excerpt

The genetic environment of plasmid-borne blaTEM mutant genes, encoding nine distinct TEM-type extended-spectrum beta-lactamases, was studied in transconjugants from clinical isolates of enterobacteria. Colony hybridization with probes specific for tnpA and tnpR of Tn3, tnpA and tnpI of Tn21, aacA4, and IS15, and restriction endonuclease analysis of plasmid DNA indicated that the structural genes for the enzymes...

Topics

Amino Acid Sequence
Base Sequence
DNA Transposable Elements
DNA, Bacterial
Drug Resistance, Microbial
Escherichia coli
Genetic Linkage
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

R Factors

beta-Lactamases

Source

Identifiers

PMID: 1331747
DOI: 10.1007/BF00286188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1331747-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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