Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.

doi:10.1093/clinids/10.4.746

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Article

Hydrolytic rate at low drug concentration as a limiting factor in resistance to newer cephalosporins.

Reviews of infectious diseases - 1 Jan 2000

Hiraoka M, Inoue M, Mitsuhashi S

Abstract excerpt

Hydrolysis kinetics of two cephalosporinases from Citrobacter freundii and Proteus vulgaris having different affinities for cefotaxime and ceftazidime was assessed in studies with cefotaxime, ceftazidime, BMY-28142, and imipenem. The two cephalosporinase genes were cloned into strains of Escherichia coli. The production of these cephalosporinases in strains of E. coli, as well as in the derepressed mutants of C....

Topics

Cefotaxime
Cefoxitin
Ceftazidime
Cell Membrane Permeability
Cephalosporinase
Cephalosporins
Citrobacter
Cloning, Molecular
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrolysis

Imipenem

Kinetics

Mutation

Proteus vulgaris

beta-Lactamases

Source

Open in PubMed

Identifiers

PMID: 3055173
DOI: 10.1093/clinids/10.4.746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3055173-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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