Article
Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424.
Antimicrobial agents and chemotherapy - 1 May 1991
Pace J, Bertasso A, Georgopapadakou N H
Abstract excerpt
Ro 23-9424 is a broad-spectrum antibacterial agent consisting of a cephalosporin (desacetylcefotaxime) linked through an ester bond to a fluoroquinolone (fleroxacin). Its activity against mutants of Escherichia coli TE18 resistant to both antibacterial components was examined. E. coli TE18 overproduces the AmpC beta-lactamase and is resistant to several cephalosporins, including desacetylcefotaxime (MIC, 50...
Topics
- Anti-Bacterial Agents
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Cefotaxime
- Cell Membrane Permeability
- Cephalosporins
- Ciprofloxacin
- Coliphages