Selection of resistant mutants of Citrobacter freundii by second and third-generation cephalosporins and imipenem.

doi:10.1007/BF01645225

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Article

Selection of resistant mutants of Citrobacter freundii by second and third-generation cephalosporins and imipenem.

Infection - 1 Jan 2000

del Rosario Valencia A M, Vuye A, Pijck J

Abstract excerpt

Using a single-step selection procedure, resistant mutants could be obtained from three clinical isolates of Citrobacter freundii with two second-generation and four third-generation cephalosporins but not with imipenem. All mutants showed a drastically increased beta-lactamase activity and were...

Topics

Cephalosporins
Citrobacter
Drug Resistance, Microbial
Humans
Imipenem
Mutation
Thienamycins
beta-Lactamases

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