Cefclidin (E1040), a novel cephalosporin: lack of selection of beta-lactamase overproducing mutants in an in vitro pharmacokinetic model system.

doi:10.7164/antibiotics.45.1335

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Article

Cefclidin (E1040), a novel cephalosporin: lack of selection of beta-lactamase overproducing mutants in an in vitro pharmacokinetic model system.

The Journal of antibiotics - 1 Aug 1992

Watanabe N A, Katsu K

Abstract excerpt

The bactericidal activity of cefclidin (E1040), a new cephalosporin, against a clinical strain of Citrobacter freundii was compared with that of ceftazidime in a two-compartment in vitro pharmacokinetic model system designed to simulate plasma concentrations in humans for 12 hours after intraveno...

Topics

Bacteria
Ceftazidime
Cephalosporins
Drug Resistance, Microbial
Enzyme Induction
Kinetics
Microbial Sensitivity Tests
Mutation
beta-Lactamases

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