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Article

Molecular Determinants of Cancer Therapy Resistance to HDAC Inhibitor-Induced Autophagy

31 Dec 2019

Abstract excerpt

Histone deacetylation inhibitors (HDACi) offer high potential for future cancer therapy as they can re-establish the expression of epigenetically silenced cell death programs. HDACi-induced autophagy offers the possibility to counteract the frequently present apoptosis-resistance as well as stress conditions of cancer cells. Opposed to the function of apoptosis and necrosis however, autophagy activated in cancer...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

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PMID: 31906235
DOI: 10.3390/cancers12010109

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