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Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway

1 Dec 2014

Abstract excerpt

BACKGROUND: Histone acetyltransferase (HAT) inhibitors can inhibit proliferation and induce apoptosis in cancer cell lines. The novel cell-permeable p300/CREB-binding protein (CBP)-selective HAT inhibitor HATi II can reduce histone H3 acetylation and induce chromatin condensation in HeLa cells. Here, we examined the effects and mechanism of action of HATi II in glioma cell lines. METHODS: Cell viability was...

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PMID: 25523932
DOI: 10.1186/s13046-014-0108-3

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