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Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability

23 Mar 2015

Abstract excerpt

Genetic instability, provoked by exogenous mutagens, is well linked to initiation of cancer. However, even in unstressed cells, DNA undergoes a plethora of spontaneous alterations provoked by its inherent chemical instability and the intracellular milieu. Base excision repair (BER) is the major cellular pathway responsible for repair of these lesions, and as deficiency in BER activity results in DNA damage it has...

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PMID: 25800737
DOI: 10.1093/nar/gkv222

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