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Article

Challenging SNP impact on caspofungin resistance by full-lengthFKS1allele replacement inCandida lusitaniae

25 Oct 2018

Abstract excerpt

OBJECTIVES: A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically engineered for full-length replacement of the FKS1 gene encoding the target of echinocandin antifungals in order to assess the impact of FKS mutations on echinocandin resistance and reduced echinocandin susceptibility (RES). METHODS: FKS1 allelic exchange was achieved by transforming C. lusitaniae with two DNA fragments...

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PMID: 30517635
DOI: 10.1093/jac/dky475

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