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Article

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion

29 Nov 2018

Abstract excerpt

Liver cholestasis is a chronic liver disease and a major health problem worldwide. Cholestasis is characterised by a decrease in bile flow due to impaired secretion by hepatocytes or by obstruction of bile flow through intra- or extrahepatic bile ducts. Thereby cholestasis can induce ductal proliferation, hepatocyte injury and liver fibrosis. Notch signalling promotes the formation and maturation of bile duct...

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PMID: 30501048
DOI: 10.3390/ijms19123801

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