Article
Association of Killer Cell Immunoglobulin-like Receptor (KIR) Genes and their HLA Ligands with Susceptibility to Takayasu Arteritis in the Iranian Population.
Iranian journal of allergy, asthma, and immunology - 20 Feb 2023
Beigmohammadi Fereshteh, Aslani Saeed, Kavosi Hoda, Javinani Ali, Mostafaei Shayan, Pournazari Mehran, Tasorian Baharak, Farhadi Elham, Hajiabbasi Asghar, Zayeni Habib, Khabbazi Alireza, Jamshidi Ahmadreza, Shenavar Masooleh Irandokht, Tamartash Zahra, Vojdanian Mahdi, Mahmoudi Mahdi
Abstract excerpt
Takayasu arteritis (TA) is a chronic inflammatory disorder characterized by vascular damage and fibrosis in the intima that commonly occurs in the aorta. In many damaged sites in TA patients, natural killer (NK) cells have been shown to be hyperactivated and produce inflammatory cytokines and toxic components. Killer cell immunoglobulin-like receptors (KIRs) are found on NK cells and interact with human leukocyte...
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