Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory T cells expressing abundant CTLA‐4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer

28 Nov 2018

Abstract excerpt

FOXP3+ regulatory T (Treg) cells suppress anti‐tumor immunity. The suppression of Treg cells is regulated by cytotoxic T‐lymphocyte‐associated antigen‐4 (CTLA‐4), whose expression on the cell surface is tightly regulated. Here we found that Treg cells expressing abundant CTLA‐4 on the cell surface (surface‐CTLA‐4+ Treg) were expanded in human head and neck cancer tissues. RNA sequencing of surface‐CTLA‐4+ and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30485427
DOI: 10.1002/ijc.32024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory T cells expressing abundant CTLA‐4 on the cell surface with a proliferative gene profile are key features of human head and neck cancerPMID 30485427Read ↗

Deciphering the immune landscape of head and neck squamous cell carcinoma: A single-cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapySemantic proximity Read ↗

Deciphering the Immune Landscape of Head and Neck Squamous Cell Carcinoma: A Single-Cell Transcriptomic Analysis of Regulatory T Cell Responses to PD-1 Blockade TherapySemantic proximity Read ↗

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory CellsSemantic proximity Read ↗

Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experimentsSemantic proximity Read ↗

IRF4 instructs effector Treg differentiation and immune suppression in human cancerSemantic proximity Read ↗

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.Semantic proximity Read ↗

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.Semantic proximity Read ↗

Induced and natural regulatory T cells in human cancer.Semantic proximity Read ↗

Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma.Semantic proximity Read ↗

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashionSemantic proximity Read ↗

Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions.Semantic proximity Read ↗

Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neckSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.