Article
Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma.
Journal of translational medicine - 4 Nov 2011
Li Jiang, Huang Zhou-Feng, Xiong Geng, Mo Hao-Yuan, Qiu Fang, Mai Hai-Qiang, Chen Qiu-Yan, He Jia, Chen Shu-Peng, Zheng Li-Min, Qian Chao-Nan, Zeng Yi-Xin
Abstract excerpt
BACKGROUND: CD8+ effector cells often have an antitumor function in patients with cancer. However, CD8+Foxp3+ regulatory T cells (Tcregs) and interleukin (IL)-17-producing CD8+ T cells (Tc17 cells) also derive from the CD8+ T cell lineage. Their role in the antitumor response remains largely unknown. In the present study, we aimed to investigate the distribution, characterization, and generation of CD8+ Tcregs...
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