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Article

The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis

28 Nov 2018

Abstract excerpt

The role of astrocytes in the pathophysiology of multiple sclerosis (MS) is discussed controversially. Especially the formation of the glial scar is often believed to act as a barrier for remyelination. At the same time, astrocytes are known to produce factors that influence oligodendrocyte precursor cell (OPC) survival. To explore these mechanisms, we investigated the astrocytic reaction in an animal model...

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PMID: 30484905
DOI: 10.1002/glia.23556

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