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Article

The bystander effect contributes to the accumulation of senescent cells in vivo

21 Nov 2018

Abstract excerpt

Senescent cells accumulate with age in multiple tissues and may cause age-associated disease and functional decline. In vitro, senescent cells induce senescence in bystander cells. To see how important this bystander effect may be for accumulation of senescent cells in vivo, we xenotransplanted senescent cells into skeletal muscle and skin of immunocompromised NSG mice. 3 weeks after the last transplantation,...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 30462359
DOI: 10.1111/acel.12848

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