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Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure

19 Nov 2018

Abstract excerpt

Global transcriptional activity increases as oocytes grow and is silenced in fully grown oocytes. Thus, the chromatin configuration varies during oocyte growth, but the molecular mechanisms regulating these changes remain to be clarified. Here, we studied a susceptibility gene of polycystic ovary syndrome (PCOS), RPS26, which is a ribosomal protein-encoding gene that is highly expressed in the ovary, but the...

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PMID: 30451825
DOI: 10.1038/s41419-018-1196-3

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