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Article

Cellular metabolism constrains innate immune responses in early human ontogeny

12 Nov 2018

Abstract excerpt

Pathogen immune responses are profoundly attenuated in fetuses and premature infants, yet the mechanisms underlying this developmental immaturity remain unclear. Here we show transcriptomic, metabolic and polysome profiling and find that monocytes isolated from infants born early in gestation display perturbations in PPAR-γ-regulated metabolic pathways, limited glycolytic capacity and reduced ribosomal activity....

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PMID: 30446641
DOI: 10.1038/s41467-018-07215-9

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