Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity

Abstract excerpt

Our data revealed significant immunometabolic perturbations in the bone marrow and myeloid cells in the newly weaned offspring born to mothers with obesity. Adaptation to an adverse maternal intrauterine environment affects bone marrow metabolism at a very young age and might affect responses to immune challenges that appear later in life, for example, infections or cancer.

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