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Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

12 Mar 2019

Abstract excerpt

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative...

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PMID: 30862783
DOI: 10.1038/s41467-019-08794-x

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