Article
Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats.
Environmental health perspectives - 1 Sept 2018
Krishnan Krittika, Mittal Nitish, Thompson Lindsay M, Rodriguez-Santiago Mariana, Duvauchelle Christine L, Crews David, Gore Andrea C
Abstract excerpt
BACKGROUND: Exposure to endocrine-disrupting chemicals (EDCs) during gestation influences development of the F1 generation offspring and can result in disease and dysfunction in adulthood. Limited evidence suggests consequences on the F2 generation, exposed as germ cells within the F1 fetus. These F2s provide a unique window into the programming effects of EDCs. OBJECTIVE: This study assessed intergenerational...
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