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Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells

14 Nov 2018

Abstract excerpt

Ebola virus and Nipah virus (EBOV and NiV) can cause fatal disease in humans. In contrast, infected fruit bats do not develop symptoms but can transmit the virus to humans. Why fruit bats but not humans control infection is largely unknown. Tetherin is an antiviral host cell protein and is counteracted by the EBOV glycoprotein in human cells. Here, employing model systems, we show that tetherin of fruit bats...

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PMID: 30429347
DOI: 10.1128/jvi.01821-18

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