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Article

Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma

1 Oct 2018

Abstract excerpt

Abstract: RTK plays important roles in many cellular signaling processes involved in cancer growth and development. ALK, TRKA, TRKB, TRKC, and ROS1 are RTKs involved in several canonical pathways related to oncogenesis. These proteins can be genetically altered in malignancies, leading to receptor activation and constitutive signaling through their respective downstream pathways. Neuroblastoma (NB) is the most...

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PMID: 30425456
DOI: 10.2147/dddt.s147384

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