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Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells

6 Nov 2018

Abstract excerpt

Autophagy is commonly described as a cell survival mechanism and has been implicated in chemo- and radioresistance of cancer cells. Whether ionizing radiation induced autophagy triggers tumor cell survival or cell death still remains unclear. In this study the autophagy related proteins Beclin1 and ATG7 were tested as potential targets to sensitize colorectal carcinoma cells to ionizing radiation under normoxic,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30412717
DOI: 10.1016/j.yexcr.2018.11.004

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