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Article

Hypoxia-Induced Autophagy Confers Resistance of Breast Cancer Cells to Ionizing Radiation

1 May 2012

Abstract excerpt

Hypoxia is a hallmark of solid tumors, which presents a major obstacle to the effectiveness of radiation therapy. However, the function and the importance of molecular response have not been well defined. In the present study, hypoxia-induced autophagy and its effect on the response of breast cancer cells to ionizing radiation were examined. Results showed that hypoxic exposure induced a marked accumulation of...

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PMID: 23581232
DOI: 10.3727/096504013x13589503483012

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