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Article

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

1 Nov 2018

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) is an important mechanism for cancer progression and metastasis. Numerous in vitro and tumor-profiling studies point to the miR-200-Zeb1 axis as crucial in regulating this process, yet in vivo studies involving its regulation within a physiological context are lacking. Here, we show that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell...

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PMID: 30405106
DOI: 10.1038/s41467-018-07130-z

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