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Polymer Thin Film–Induced Tumor Spheroids Acquire Cancer Stem Cell–like Properties

23 Oct 2018

Abstract excerpt

: Although cancer stem cells (CSC) are thought to be responsible for tumor recurrence and resistance to chemotherapy, CSC-related research and drug development have been hampered by the limited supply of diverse, patient-derived CSC. Here, we present a functional polymer thin film (PTF) platform that promotes conversion of cancer cells to highly tumorigenic three-dimensional (3D) spheroids without the use of...

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PMID: 30352813
DOI: 10.1158/0008-5472.can-18-0927

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