Article
A scalable microbead-based cell culture platform presenting curvature cues for the enrichment of cancer stem cell-like phenotypes beyond 3D spheroid models.
Biomaterials advances - 1 Jun 2026
Yeun Jemin, Kim JeongYeon, Kim Minkyung, Park Seonghyeon, Yoon Sung Hyun, Sun Sang Yu, Jeong Booseok, Im Sung Gap, Baek Jieung
Abstract excerpt
Cancer stem cells (CSCs) have been implicated as potential contributors to tumor recurrence, therapeutic resistance, and metastatic behavior. While traditional 3D spheroid models have advanced CSC research, their multilayered architecture introduces cellular heterogeneity and limits reproducibility. Here, we present a 3D microbead-based culture platform that enables spatially uniform induction of CSC-like...
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