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Innate Immune Sensing of Adeno-Associated Virus Vectors

18 Jun 2024

Abstract excerpt

Adeno-associated virus (AAV) based viral vectors are widely used in human gene therapy and form the basis of approved treatments for several genetic diseases. Immune responses to vector and transgene products, however, substantially complicate these applications in clinical practice. The role of innate immune recognition of AAV vectors was initially unclear, given that inflammatory responses early after vector...

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PMID: 38887999
DOI: 10.1089/hum.2024.040

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