Article

Identification of Germline Cancer Predisposition Variants During Clinical Ctdna Testing

2021-03-02

Abstract excerpt

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) is a non-invasive method to guide therapy selection for cancer patients. ctDNA variant allele frequency (VAF) is commonly reported and may aid in discerning whether a variant is germline or somatic. We report on the fidelity of VAF in ctDNA as a predictor for germline variant carriage. Two patient cohorts were studied. Cohort 1 included patients wit...

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Literature Corpus work: 7b12d520-3603-593c-b7b7-5c6df0506ad3
DOI: 10.21203/rs.3.rs-256641/v1

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