Article
Comprehensive Profiling of the Androgen Receptor in Liquid Biopsies from Castration-resistant Prostate Cancer Reveals Novel Intra-AR Structural Variation and Splice Variant Expression Patterns.
European urology - 1 Aug 2017
De Laere Bram, van Dam Pieter-Jan, Whitington Tom, Mayrhofer Markus, Diaz Emanuela Henao, Van den Eynden Gert, Vandebroek Jean, Del-Favero Jurgen, Van Laere Steven, Dirix Luc, Grönberg Henrik, Lindberg Johan
Abstract excerpt
BACKGROUND: Expression of the androgen receptor splice variant 7 (AR-V7) is associated with poor response to second-line endocrine therapy in castration-resistant prostate cancer (CRPC). However, a large fraction of nonresponding patients are AR-V7-negative. OBJECTIVE: To investigate if a comprehensive liquid biopsy-based AR profile may improve patient stratification in the context of second-line endocrine...
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