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Fertility Enhancement but Premature Ovarian Failure in esr1-Deficient Female Zebrafish

24 Sept 2018

Abstract excerpt

It is well established that estrogens regulate female reproduction through estrogen receptors (ERs) in the ovary. However, the precise physiological role of estrogen/ER signaling in reproduction processes remains poorly defined in zebrafish. In this study, we successfully generated an ERα (esr1) mutant line in zebrafish via transcription activator-like effectors nucleases (TALENs). It was found in the mutant...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Reproductive biology and impacts on aquatic species

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30319547
DOI: 10.3389/fendo.2018.00567

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